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References
- Dexmedetomidine: What's New for Pediatrics? A Narrative Review.J Clin Med. 2020; 9https://doi.org/10.3390/jcm9092724
- Evolving spectrum of dexmedetomidine preconditioning for Ischemia-reperfusion injury amelioration.J Anaesthesiol Clin Pharmacol. 2020; 36: 272-273
- Dexmedetomidine vs midazolam as preanesthetic medication in children: a meta-analysis of randomized controlled trials.Paediatr Anaesth. 2015; 25: 468-476
- The effects of intranasal dexmedetomidine premedication in children: a systematic review and meta-analysis.Can J Anaesth. 2017; 64 (Les effets d'une premedication intranasale de dexmedetomidine chez l'enfant : revue systematique et meta-analyse): 947-961
- Premedication for anxiety in adult day surgery.Cochrane Database Syst Rev. 2009; : CD002192
- A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine.Anesth Analg. 2007; 105: 374-380
- Intranasal atomized dexmedetomidine for sedation during third molar extraction.Int J Oral Maxillofac Surg. 2013; 42: 857-862
- Intranasal Dexmedetomidine as a Sedative Premedication for Patients Undergoing Suspension Laryngoscopy: A Randomized Double-Blind Study.PLoS One. 2016; 11e0154192
- Intranasal dexmedetomidine in elderly subjects with or without beta blockade: a randomised double-blind single-ascending-dose cohort study.Br J Anaesth. 2020; : 3https://doi.org/10.1016/j.bja.2019.12.025
- The Effect of Dexmedetomidine on Emergence Agitation or Delirium in Children After Anesthesia-A Systematic Review and Meta-Analysis of Clinical Studies.Front Pediatr. 2020; 8: 329https://doi.org/10.3389/fped.2020.00329
- Comparison of dexmedetomidine with chloral hydrate as sedatives for pediatric patients: A systematic review and meta-analysis.Medicine (Baltimore). 2020; 99e21008https://doi.org/10.1097/MD.0000000000021008
- Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study.Br J Anaesth. 2018; 120: 1056-1065
- A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops.Anaesthesia. May 2016; 71: 522-528
- Effects of dexmedetomidine sedation on the EEG in children.Paediatr Anaesth. 2009; 19: 1175-1183
- Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography.J Neurosurg Anesthesiol. 2007; 19: 38-44
- Auditory brainstem response testing using intranasal dexmedetomidine sedation in children: a pilot study.Int J Audiol. 2021; 60: 549-554
- A randomized controlled trial of oral chloral hydrate vs intranasal dexmedetomidine plus buccal midazolam for auditory brainstem response testing in children.Paediatr Anaesth. 2018; 28: 1022-1028
- Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety.PLoS One. 2017; 12e0169525
- Premedication with dexmedetomidine for prevention of hyperdynamic response after electroconvulsive therapy: a cross-over, randomized controlled trial.BMC Psychiatry. 2021; 21: 408
- Outcome of four pretreatment regimes on hemodynamics during electroconvulsive therapy: A double-blind randomized controlled crossover trial.Ann Card Anaesth. 2017; 20: 93-99
- A systematic review and meta-analysis of the safety and efficacy of remifentanil and dexmedetomidine for awake fiberoptic endoscope intubation.Medicine (Baltimore). 2021; 100e25324
- A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation.J Clin Anesth. 2010; 22: 35-40
- Conscious sedation for awake fibreoptic intubation: a review of the literature.Can J Anaesth. 2013; 60: 584-599
- The effectiveness of dexmedetomidine infusion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation.Eur J Anaesthesiol. 2010; 27: 36-40
- A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children.Anesth Analg. 2009; 109: 745-753
- Comparison of the combination of dexmedetomidine and ketamine to propofol or propofol/sevoflurane for drug-induced sleep endoscopy in children.Paediatr Anaesth. 2016; 26: 742-751
- Effect of increasing depth of dexmedetomidine and propofol anesthesia on upper airway morphology in children and adolescents with obstructive sleep apnea.J Clin Anesth. 2013; 25: 529-541
- The role of dexmedetomidine in neurosurgery.Best Pract Res Clin Anaesthesiol. 2021; 35: 221-229
- Anaesthesia for deep brain stimulation: a review.Curr Opin Anaesthesiol. 2015; 28: 505-510
- Dexmedetomidine and arousal affect subthalamic neurons.Mov Disord. 2008; 23: 1317-1320
- Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists.Nat Neurosci. 2015; 18: 553-561
- Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy.Exp Ther Med. 2016; 11: 1128-1134
- Effect of dexmedetomidine on evoked-potential monitoring in patients undergoing brain stem and supratentorial cranial surgery.Acta Anaesthesiol Scand. 2021; 65: 1043-1053
- Susceptibility of transcranial electric motor-evoked potentials to varying targeted blood levels of dexmedetomidine during spine surgery.Anesthesiology. 2010; 112: 1364-1373
- Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial.Lancet. 2020; 396: 177-185
- The Influence of Perioperative Dexmedetomidine on Patients Undergoing Cardiac Surgery: A Meta-Analysis.PLoS One. 2016; 11e0152829
- Efficacy of prophylactic dexmedetomidine in preventing postoperative junctional ectopic tachycardia in pediatric cardiac surgery patients: A systematic review and meta-analysis.Paediatr Anaesth. 2018; 28: 597-606
- Outcomes of dexmedetomidine treatment in pediatric patients undergoing congenital heart disease surgery: a meta-analysis.Paediatr Anaesth. 2016; 26: 239-248
- A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine-Ketamine Combination Sedation for Transthoracic Echocardiography in Pediatric Patients With Congenital Heart Disease: A Randomized Controlled Trial.J Cardiothorac Vasc Anesth. 2020; 34: 1550-1555
- Evaluation of the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease.BMC Anesthesiol. 2018; 18: 104
- Nebulized dexmedetomidine improves pulmonary shunt and lung mechanics during one-lung ventilation: a randomized clinical controlled trial.PeerJ. 2020; 8: e9247
- The Anti-inflammatory Effect of Dexmedetomidine Administration on Patients Undergoing Intestinal Surgery: A Randomized Study.Drugs R D. 2021; 21: 445-453
- Low-Dose Dexmedetomidine Accelerates Gastrointestinal Function Recovery in Patients Undergoing Lumbar Spinal Fusion.Front Pharmacol. 2019; 10: 1509
- Effect of dexmedetomidine on hepatic ischemia-reperfusion injury in the setting of adult living donor liver transplantation.Clin Transpl. 2016; 30: 470-482
- Perioperative Dexmedetomidine Improves Outcomes of Kidney Transplant.Clin Transl Sci. 2020; 13: 1279-1287
- Intraoperative Low-Dose Dexmedetomidine Administration Associated with Reduced Hepatic Ischemia-Reperfusion Injury in Pediatric Deceased Liver Transplantation: A Retrospective Cohort Study.Ann Transplant. 2021; 26e933354https://doi.org/10.12659/AOT.933354
- Effect of Anesthesia on the Developing Brain: Infant and Fetus.Fetal Diagn Ther. 2018; 43: 1-11
- Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1-Bax signaling.Drug Des Devel Ther. 2018; 12: 3617-3624
- Dexmedetomidine versus midazolam for gastrointestinal endoscopy: a meta-analysis.Dig Endosc. 2015; 27: 8-15
- Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis.Braz J Anesthesiol. 2021; https://doi.org/10.1016/j.bjane.2021.12.002
- The Effect of Obesity on Dose of Dexmedetomidine When Administered with Fentanyl during Postoperative Mechanical Ventilation--Retrospective.Fukushima J Med Sci. 2015; 61: 38-46
- Pharmacokinetic and pharmacodynamics of intravenous dexmedetomidine in morbidly obese patients undergoing laparoscopic surgery.J Anesth. 2017; 31: 813-820
- Dexmedetomidine pharmacokinetics in the obese.Eur J Clin Pharmacol. 2015; 71: 1501-1508
- Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients.Br J Anaesth. 2018; 120: 969-977
- Dose adjustment of anaesthetics in the morbidly obese.Br J Anaesth. 2010; 105 (i16–23)
- Current methods of sedation in dental patients - a systematic review of the literature.Med Oral Patol Oral Cir Bucal. 2016; 21: e579-e586
- Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation.Anesth Pain Med. 2019; 9e85227
- A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.Anesth Analg. 2015; 121: 167-171
- Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study.Clin J Pain. 2018; 34: 811-817
- Dexmedetomidine Added to Ropivacaine for Ultrasound-guided Erector Spinae Plane Block Prolongs Analgesia Duration and Reduces Perioperative Opioid Consumption After Thoracotomy: A Randomized, Controlled Clinical Study.Clin J Pain. 2021; 38: 8-14
- Comparative analgesic, hemodynamic, pain and duration of sensory and motor block effects of dexmedetomidine, granisetron, and nitroglycerin added to ropivacaine in intravenous anesthesia for forearm surgeries: a randomized clinical study.Med Gas Res. 2022; 12: 77-82
- Evidence basis for using perineural dexmedetomidine to enhance the quality of brachial plexus nerve blocks: a systematic review and meta-analysis of randomized controlled trials.Br J Anaesth. 2017; 118: 167-181
- Optimal dose of perineural dexmedetomidine to prolong analgesia after brachial plexus blockade: a systematic review and Meta-analysis of 57 randomized clinical trials.BMC Anesthesiol. 2021; 21: 233
- Alpha-2 adrenergic agonists for the prevention of cardiac complications among adults undergoing surgery.Cochrane Database Syst Rev. 2018; 3: CD004126
- Use of Dexmedetomidine in Cardiothoracic and Vascular Anesthesia.J Cardiothorac Vasc Anesth. 2018; 32: 1426-1438
- Greater incidence of delirium during recovery from sevoflurane anesthesia in preschool boys.Anesthesiology. 1997; 87: 1298-1300
- Emergence agitation after sevoflurane versus propofol in pediatric patients.Anesth Analg. 2000; 91: 563-566
- Assessing behaviour in children emerging from anaesthesia: can we apply psychiatric diagnostic techniques?.Paediatr Anaesth. 2003; 13: 609-616
- Emergence delirium in children: many questions, few answers.Anesth Analg. 2007; 104: 84-91
- Risk factors for emergence agitation in adults after general anesthesia: A systematic review and meta-analysis.Acta Anaesthesiol Scand. 2021; 65: 719-729
- Paediatric emergence delirium: a comprehensive review and interpretation of the literature.Br J Anaesth. 2017; 118: 335-343
- Effects of Dexmedetomidine on Emergence Agitation and Recovery Quality Among Children Undergoing Surgery Under General Anesthesia: A Meta-Analysis of Randomized Controlled Trials.Front Pediatr. 2020; 8580226
- Dexmedetomidine for preventing sevoflurane-related emergence agitation in children: a meta-analysis of randomized controlled trials.Acta Anaesthesiol Scand. 2014; 58: 642-650
- Optimal Dexmedetomidine Dose to Prevent Emergence Agitation Under Sevoflurane and Remifentanil Anesthesia During Pediatric Tonsillectomy and Adenoidectomy.Front Pharmacol. 2019; 10: 1091https://doi.org/10.3389/fphar.2019.01091
- Dexmedetomidine as a Rapid Bolus for Treatment and Prophylactic Prevention of Emergence Agitation in Anesthetized Children.Anesth Analg. 2015; 121: 1308-1315
- Intraoperative use of low-dose dexmedetomidine for the prevention of emergence agitation following general anaesthesia in elderly patients: a randomized controlled trial.Aging Clin Exp Res. 2021; https://doi.org/10.1007/s40520-021-01984-y
- Shivering prevention and treatment during cesarean delivery under neuraxial anesthesia: a systematic review.Minerva Anestesiol. 2018; 84: 1393-1405
- Effectiveness of dexmedetomidine use in general anesthesia to prevent postoperative shivering: a systematic review.JBI Database Syst Rev Implement Rep. 2016; 13: 287-313
- Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials.Drug Des Devel Ther. 2019; 13: 2933-2939
- Intravenous dexmedetomidine versus tramadol for treatment of shivering after spinal anesthesia: a meta-analysis of randomized controlled trials.BMC Anesthesiol. 2020; 20: 104
- Optimal dose of prophylactic dexmedetomidine for preventing postoperative shivering.Int J Med Sci. 2013; 10: 1327-1332
- The effects of novel alpha2-adrenoreceptor agonist dexmedetomidine on shivering in patients underwent caesarean section.Biosci Rep. 2019; 28: 39https://doi.org/10.1042/BSR20181847
- Association of dexmedetomidine with recovery room and hospital discharge times: A retrospective cohort analysis.Paediatr Anaesth. 2021; 31: 1170-1178
- The effect of intraoperative dexmedetomidine administration on length of stay in the post-anesthesia care unit in ambulatory surgery: A hospital registry study.J Clin Anesth. 2021; 72110284
- Efficacy and Safety of Intranasal Dexmedetomidine During Recovery From Sevoflurane Anesthesia in Children: A Systematic Review and Meta-analysis.Clin Neuropharmacol. 2021; 44: 157-168
- The Effect of Dexmedetomidine on Postanesthesia Care Unit Discharge and Recovery: A Systematic Review and Meta-Analysis.Anesth Analg. 2022; https://doi.org/10.1213/ane.0000000000005843
- FDA. Dexmedetomidine package insert.(Available at:) (Accessed March 8 2022)
- Efficacy and Safety of Dexmedetomidine for Prolonged Sedation in the PICU: A Prospective Multicenter Study (PROSDEX).Pediatr Crit Care Med. 2020; 21: 625-636
- Dexmedetomidine as Single Continuous Sedative During Noninvasive Ventilation: Typical Usage, Hemodynamic Effects, and Withdrawal.Pediatr Crit Care Med. 2018; 19: 287-297
- Dexmedetomidine for Prolonged Sedation in the PICU: A Systematic Review and Meta-Analysis.Pediatr Crit Care Med. 2020; 21: e467-e474
- Efficacy and safety of sedation with dexmedetomidine in critical care patients: a meta-analysis of randomized controlled trials.Anaesth Crit Care Pain Med. 2016; 35: 7-15
- Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review.Health Technol Assess Mar. 2016; 20 (v-xx): 1-117
- Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.Cochrane Database Syst Rev. 2015; 1: Cd010269
- Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation: A Systematic Review and Meta-analysis of Randomized Trials.Chest. 2021; 159: 2274-2288
- Incidence of Dexmedetomidine Withdrawal in Adult Critically Ill Patients: A Pilot Study.Crit Care Explor. 2019; 1e0035
- Clonidine as a strategy for discontinuing dexmedetomidine sedation in critically ill patients: A narrative review.Am J Health Syst Pharm. 2020; 77: 515-522
- Prevention of Withdrawal in Pediatric Patients Receiving Long-term Dexmedetomidine Infusions.J Pediatr Pharmacol Ther. 2021; 26: 81-86
- The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial.Crit Care. 2020; 24: 441
- The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial.Crit Care Med. 2019; 47: e89-e95
- Perioperative dexmedetomidine reduces delirium after cardiac surgery: A meta-analysis of randomized controlled trials.J Clin Anesth. 2018; 50: 33-42
- Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis.Eur J Anaesthesiol. 2020; 37: 121-131
- Comparison of the Effects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit.Anesth Pain Med. 2021; 11e113802
- Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.Am J Respir Crit Care Med. 2018; 197: 1147-1156
- Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial.JAMA Surg. 2017; 152e171505
- Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients.Pharmacotherapy. 2016; 36: 797-822
- Dexmedetomidine: A Novel Strategy for Patients with Intractable Pain, Opioid-Induced Hyperalgesia, or Delirium at the End of Life.J Palliat Med. 2020; 23: 1515-1517
- The Use of Dexmedetomidine in Pediatric Palliative Care: A Preliminary Study.J Palliat Med. 2017; 20: 779-783
- Dexmedetomidine facilitates the withdrawal of ventilatory support in palliative care.Anesthesiology. 2005; 103: 439-441
- Home Intranasal Dexmedetomidine for Refractory Dystonia in Pediatric Palliative Care.J Pain Symptom Manage. 2020; 59: e3-e5
- Intranasal dexmedetomidine: Procedural sedation in palliative care: A case report.Palliat Med. 2021; 35: 1625-1628
- Subcutaneous dexmedetomidine for baclofen withdrawal during palliative sedation.BMJ Support Palliat Care. 2020; 10: 7-9
- Dexmedetomidine for hyperactive delirium at the end of life: An open-label single arm pilot study with dose escalation in adult patients admitted to an inpatient palliative care unit.Palliat Med. 2021; 35: 729-737
- An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.Anesth Analg. 2009; 108: 906-908
- Evaluation of the sedative and cardiovascular effects of intramuscular administration of dexmedetomidine with and without concurrent atropine administration in dogs.J Am Vet Med Assoc. 2011; 239: 81-89
- To Pretreat or Not to Pretreat: Prophylactic Anticholinergic Administration Before Dexmedetomidine in Pediatric Imaging.Anesth Analg. 2015; 121: 479-485
- Intranasally Administered Adjunctive Dexmedetomidine Reduces Perioperative Anesthetic Requirements in General Anesthesia.Yonsei Med J. 2016; 57: 998-1005
- Optimal Dose of Intrathecal Dexmedetomidine in Lower Abdominal Surgeries in Average Indian Adult.J Clin Diagn Res. 2016; 10 (UC09–13)
- Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia.Indian J Anaesth. 2011; 55: 347-351
- Safety and Efficacy of Dexmedetomidine in Treating Post Spinal Anesthesia Shivering: A Randomized Clinically Controlled Dose-Finding Trial.Pain Physician. 2016; 19: 243-253
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